CURRENT ISSUE
EDITOR'S PICKS
Perspective Article
T-cell clones of uncertain significance. When is the rogue clone dangerous?
ARTICLES IN THREE SENTENCES
Article
Immunoglobulin prophylaxis prevents hospital admissions for fever in pediatric acute lymphoblastic leukemia: results of a multicenter randomized trial
Infections lead to substantial morbidity during the treatment of acute lymphoblastic leukemia (ALL). Investigators of a Dutch ALL study (DCOG ALL-11) report the first multicenter, randomized trial investigating the effect of intravenous immunoglobulin (IVIG) in children with ALL. Results show that IVIG prophylaxis is associated with significantly fewer admissions for fever during maintenance treatment, resulting in fewer courses of antibiotic treatment and fewer chemotherapy adaptations.
Letter
Characteristics and outcomes associated with CD2 and CD25 expression on bone marrow mast cells in patients with systemic mastocytosis
The identification of prognostic factors for time to treatment failure and overall survival of patients with advanced systemic mastocytosis (SM) is critical for the optimization of patients’ care. Rossignol and colleagues investigated the characteristics and outcomes of SM patients as a function of their bone marrow mononuclear cell expression of CD2 and CD25. They demonstrated a poor prognostic significance of the lack of CD2 that may serve as a cost-effective tool for identifying patients with advanced SM at high risk, especially when next-generation sequencing, and thus the Mutation-Adjusted Risk Score, is not available.
Article
Hodgkin/Reed-Sternberg cells induce GPNMB expression and release from macrophages to suppress T-cell responses to the Epstein-Barr virus-encoded LMP2A protein
The inflammatory tumor microenvironment (TME) is thought to prevent immune recognition of Hodgkin/Reed-Sternberg cells by tumor-specific T cells, but the mechanisms responsible are poorly understood. Masand and colleagues report that tumor-associated macrophages in the TME of classical Hodgkin lymphoma (cHL) strongly express glycoprotein non-metastatic B (GPNMB). Importantly, soluble recombinant GPNMB inhibited CD8+ T-cell recognition of Epstein-Barr virus-derived tumor epitopes in cHL cells, suggesting that blocking GPNMB in the TME of cHL could enhance tumor-specific CD8+ T-cell recognition.
Article
Single-cell proteo-transcriptomic profiling reveals altered characteristics of stem and progenitor cells in patients receiving cytoreductive hydroxyurea in early-phase chronic myeloid leukemia
Therapy-resistant leukemic stem and progenitor cells (SPC) are responsible for the need for lifelong treatment in some patients with chronic myeloid leukemia (CML). No studies have evaluated to what extent pretreatment with hydroxyurea in CML affects the phenotype of SPC. Through targeted proteo-transcriptomic analysis, Komic and colleagues demonstrated that hydroxyurea leads to differentiation of erythroid progenitor cells and alters the characteristics of SPC in CML.
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